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Circadian rhythm abnormalities Patients with BD suffer from sleep disturbance, which is intimately associated with circadian rhythm disturbances and an underlying deficiency or epigenetic modulation of BMAL1/ARNTL and CLOCK (circadian locomotor output cycles kaput), the two main transcriptional factors for circadian clock genes

[35] Ferner nehmen die Patienten nach dem Absetzen der Therapie gem Ergebnissen aus der STEP-4-Studie wieder an Gewicht zu

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