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Therefore, decreased NCOA4 expression and impaired binding of NCOA4 to FTH1 diminish the FTH1 degradation by downregulating ferritinophagy, and decreased FPN1 expression inhibits iron output and release to other tissues, both of which effectively increase liver iron overload and, in turn, trigger oxidative stress and ferroptosis (82)
A.CaccioppoliC.Andrulli BuccheriV.CignarelliA.et al (2017)
Lv X, Wang H, Chen C, Zhao Y, Li K, Wang Y, et al
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These mechanistic insights align with emerging clinical observations linking semaglutide to altered menstrual cyclicity, luteal insufficiency, nutrient deficiencies, and potentially impaired reproductive function
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