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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

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It is also worth noting that unexplained weight gain or difficulty losing weight despite lifestyle changes may itself be a sign of an underlying condition such as hypothyroidism or insulin resistance, both of which can impair fertility

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The standard starting dose for this medication is 2.5 mg