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While earlier studies suggested a diminished insulinotropic response to GIP in individuals with obesity and type 2 diabetes, more recent evidence indicates that pharmacologic GIP receptor activation can exert beneficial metabolic effects when combined with GLP-1 receptor agonism

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In clinical trials, participants taking oral semaglutide experienced significant weight reduction

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"By strengthening oversight of imported APIs and cracking down on illegal drugs entering the U.S., we are taking aggressive action to protect consumers from poor-quality or dangerous GLP-1 drugs." The FDA said it will continue to work with state regulators, monitor the market and take enforcement actions as necessary