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Alimentary Pharmacology & Therapeutics, 17 (4), 595-601

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Some practical dietary strategies include: Smaller portion sizes : Eating until comfortably satisfied rather than full reduces the risk of nausea and discomfort Bland, easily digestible foods : During dose escalation, focus on lean proteins, whole grains, and cooked vegetables Adequate hydration : Sipping water throughout the day, particularly if experiencing nausea or constipation Avoiding trigger foods : Identifying and temporarily limiting foods that worsen individual symptoms Persistent vomiting or diarrhea can lead to dehydration and potentially acute kidney injury

(Low to moderate coffee consumption in those regular coffee drinkers does not seem to have the same pee-inducing effect.) However, its worth noting that the amount of caffeine needed to cause a diuretic effect is above the daily recommended limit anyway

Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells