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Retatrutide groups: ~ 75% reduction in WOMAC pain score Placebo group: 40.3% reduction [9] Comparison With Other Medications Semaglutide (Ozempic) 68-week trial ~15% average weight loss In overweight/obese participants without diabetes [10] Tirzepatide 72-week trial Highest dose (15 mg): ~ 21% average weight loss 2,539 participants without diabetes [11] Takeaway Retatrutide clearly sets a new bar for weight loss effectiveness but thats not the full story