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International Journal of Molecular Sciences, 2013
Important factors for the loading phase include: Severity of initial deficiency Presence of neurological symptoms Patients overall health status Response to initial doses as assessed through follow-up laboratory tests By following this guideline, doctors can quickly restore vitamin B12 levels
In vitro, 5-Amino-1MQ at 30 M in 3T3-L1 adipocytes significantly reduced intracellular 1-MNA levels, confirming NNMT target engagement
Additional analyses quantified 38 low-molecular-weight metabolites (e.g., citrate, lactate, leucine) using the Bruker IVDr quantification in Plasma/Serum(B.I.Quant-PS) method, along with five inflammatory markers (including GlycA and GlycB) via the Bruker IVDr B.I.-PACS method (Table S2)
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