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Although a variety of tumour immunotherapeutic medicines have been developed, their broad use has been constrained by difficulties in their administration, including poor tumour permeability and low tumour cell absorption rates ( Currently, immunotherapy is a novel option for many solid tumours that have failed conventional therapies

The liver plays a prominent role in the II

It has shown a strong safety profile in animal research and good tolerance in human research subjects, but large-scale human clinical trials are still needed

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