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However, they determined that the strength of the evidence for these associations was limited, and some of the studies did not adequately correct for potential confounders such as the severity of depression, hormone levels, and lifestyle factors, among other variables

Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

Animal studies show low acute toxicity, but human safety data remain limited,,

Cancer 20 , 772780 (2010)

Practitioners in skincare forums often emphasize this point

Avoid excessive training that creates recovery debt or spikes cortisol