In the first cohort (interventional study), patients (15 men, 30 women) were randomly assigned 1:1:1 to undergo metabolic Roux-en-Y gastric bypass (mRYGB), Sleeve gastrectomy (SG), or Greater curvature plication (GCP) (the latter two referred as restrictive)
Cholangiocarcinomacomposed of malignant duct epithelium
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Importantly, persistent activation of NRF2 that is induced pharmacologically in KEAP1-NRF2-intact cancer cells also decreases NEAA synthesis and makes them rely on exogenous NEAAs (LeBoeuf et al
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