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The SUSTAIN clinical trial programme has documented Semaglutides superior glycaemic and weight-reducing efficacy relative to placebo, sitagliptin, exenatide extended-release, insulin glargine, and dulaglutide establishing Semaglutide as the highest-efficacy selective GLP-1R agonist in comparative clinical pharmacology and providing the translational reference dataset for pre-clinical mechanistic research into the molecular basis of its superior outcomes

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Broad familiarity among endocrinologists and primary care physicians carried over from type 2 diabetes care continues to reinforce its clinical dominance

Those fats remain trapped in liver cells, impairing metabolic function and creating the inflammatory environment that promotes insulin resistance