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A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

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This neurovascular coupling could be elucidated by monitoring the dynamic changes of the regional cerebral arterial blood flow

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Previous studies have documented bacterial selenoproteins involved in redox metabolism, including a glutaredoxin in Clostridium oremlandii [42] and a thioredoxin in Treponema denticola [42]