The concern surrounding Gilberts syndrome and paracetamol is based on the putative theory that a reduction in the glucuronidation of paracetamol leaves a greater fraction of the drug available to be oxidised, potentially causing toxicity
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Furthermore, direct GSSG delivery into cells via microinjection induces neural cell death via a 12-lipoxygenase pathway 36
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A lack of it can cause tiredness, changes in the nervous system, and megaloblastic anemia