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Additional renal effects of hyperuricemia include metabolic acidosis caused by defective lactic acid excretion which in turn exacerbates the hyperuricemia due to reduced urate excretion

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In cells, glutathione is maintained in the reduced form by the enzyme glutathione reductase, which reduces the disulfide form of the molecule (GSSG, glutathione disulfide) back to GSH

Patients with very low body fat may use a 5/16-inch needle