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The higher bioavailability translates to more predictable therapeutic exposure
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In this stage, two different catalysts would be produced (Table 1) (Kawai et al., 2019): the surface modification enzymes (associated with enzymatic modification of PET to increase the surface hydrophilicity) and the PET-degrading enzymes (capable of directly breaking the ester bonds within the PET polymer releasing monomeric products)
Overexpression of IGF-IR in prostate cancer is associated with high Gleason grade and increased risk of tumor recurrence and metastasis [41]
Additionally, patients with SCD, MCI, or dementia were required to have the ability to provide informed consent, demonstrated by a mini-mental state examination (MMSE) score greater than 17/30
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