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Average Weight Loss with GLP-1 Medications Clinical studies and real-world data show that patients using GLP-1 medications experience substantial weight loss: Semaglutide : Patients typically lose 15% of their body weight over 1218 months when paired with a balanced diet and regular exercise

Side effects of oral GLP-1s All medications have a risk of side effects

In additional sensitivity analyses based on the efficacy estimand, participants in cohort 1 randomized only to orforglipron in ATTAIN-MAINTAIN had a mean baseline body weight of 115.8 kg (s.e.m

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