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Poria cocos acidic polysaccharides (PCAP) significantly reduced the mRNA and protein expression levels of NLRP3, ASC, caspase-1, IL-1, and IL-18 in the prefrontal cortex of rats in a chronic unpredictable stress model ( Gastrodia elata polysaccharides (GEP) exhibited the ability to attenuate the relative mRNA expression of pro-inflammatory cytokines TNF- and IL-1 in hippocampal tissues of depressed mice, thereby exerting a neuroprotective effect and ameliorating LPS-induced depressive-like behaviors in mice ( Momordica charantia polysaccharides (MCP, 200 and 400 mg/kg) also decreased hippocampal levels of IL-1, IL-6, and TNF-, alleviating depressive behaviors in mice subjected to chronic social frustration stress ( The intervention of Astragalus polysaccharide (APS) significantly reduced the levels of hippocampal TNF-, IL-1, and IL-6 in rats with CUS-induced depression ( Polygonatum sibiricum polysaccharide (PSP) may exert antidepressant effects by inhibiting the activation of NF-B expression and nuclear translocation in mouse models of depression induced by LPS and CUS ( Yan et al

b BLI assay as in (a) but performed with isolated dimeric WDR26 construct (in the absence of YPEL5), thus probing YPEL5 dependence of the ZZ1-SO 2 H-induced ternary complex