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Even patients with genetic variants associated with lower GLP-1 sensitivity benefit from these medications, though they may require higher doses or dual-compound therapy like GLP-Squared

These individuals may experience various complications, such as cardiovascular disease (including type 2 diabetes, hypertension, and hyperlipidemia), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic syndrome (MS), and endometrial cancer (EC) ( 3.4.1 Protective effects of metformin on cardiovascular disease risk in patients with polycystic ovary syndrome Epidemiological research suggests that individuals with PCOS exhibit a greater prevalence of hypertension compared to those without PCOS, particularly among females of reproductive age, and their cardiovascular risk is notably elevated irrespective of their BMI

Terapias que influenciam no metabolismo muscular podem ser, portanto, efetivas para a melhora do desempenho 14,16,17

Improved energy levels and reduced feelings of fatigue

evaluated the precise effects of L-carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress

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