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Park et al., 2020), its relationship to the nitric oxide (NO)-system (Sikiric et al., 2014), and blood vessels (Sikiric et al., 2006

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In the absence of a known mechanism for this association, we urge clinicians to weigh the concern for an increased risk of a rare but potentially blinding eye condition with the many therapeutic benefits of semaglutide. 1 A commentary also published yesterday was written by coauthors of the July 2024 JAMA Ophthalmology study with the higher risk estimates

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Weight Management: While not a weight-loss drug, the modest weight loss or weight-neutral effect associated with metformin can be beneficial for overweight or obese patients with diabetes