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Although data on HR were not provided in most studies of twice-daily exenatide, HR elevation was generally more apparent in the GLP-1 RA treatment arms, compared with the comparator arms (Table 2)

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[21] [22] Patients with pre-existing gastroparesis or severe gastrointestinal disease were excluded from major clinical trials, and the FDA label specifically states that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

doi: 10.1039/c6fo00107f