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Whereas vitamin C enters cells through sodium cotransporters, DHA competes with glucose for uptake through glucose transporters (particularly GLUT1 and GLUT4) and then is reduced back to vitamin C in cells 2 (Figure 1)

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Bioorg Chem 86:339345 Alcolea V et al (2021) 3, 5-Dimethyl-4-isoxazoyl selenocyanate as promising agent for the treatment of Leishmania infantum -infected mice

The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion

Regulation is achieved also by post-translational modifications (PTMs) as phosphorylation or myristoylation and by allosteric effectors like NADPH [20]

A previous study analyzing U87MG human GBM cells in vitro found that when treated with a specific concentration of noscapine, the anti-tumor effects of TMZ, Bischloroethyl Nitrosourea (BCNU), and cisplatin were increased (168, 172)