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GHK-Cu works through copper delivery to metalloenzymes and broad gene expression modulation, affecting not only collagen synthesis but also collagen cross-linking (via lysyl oxidase), glycosaminoglycan production, anti-inflammatory pathways, and antioxidant defense systems

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showed the possible role of nuclear GSTpi in the acquisition of resistance to anticancer drugs by cancer cells (66, 67), it is unclear how GSTP translocated from the cytoplasm to nucleus and if in the macrophage, cytosolic GSTP could also enter into the nucleus

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D.ThompsonD

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mean waist circumference was 105 cm

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