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Prescribing population We identified patients aged 18 years or older who were prescribed a GLP-1 between January 2024 and February 2026

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This action not only assists in controlling blood sugar levels but also significantly reduces hunger and slows the transit of food through the digestive system

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As obesity is known to increase the risk of cardiovascular disease, including HF, therefore, anti-obesity interventions like tirzepatide may have cardioprotective effects [101]

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We therefore took an unbiased genome-wide approach to identify transcriptional targets of GLP-1 signaling, through intersection of genes identified as directly bound by LAG-1, from Chromatin immunoprecipitation (ChIP) experiments, with genes that were identified as requiring GLP-1 signaling for RNA accumulation, from RNA-seq transcriptomics analysis

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