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Doherty, J

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Multi-target mechanisms of phytochemicals in Alzheimers disease: effects on oxidative stress, neuroinflammation and protein aggregation

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AICAR, an intermediate of de novo purine synthesis, was decreased, compatible with brisk flux toward IMP and a relative loss of AMPK control that otherwise restrains inflammatory programs ( 6 -methyladenosine (m 6 A), the dominant internal mRNA modification in plasma, was decreased

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