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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

Illegal sales complicate the safety situation further

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examined the effects of administering growth hormone at different times of day in prepubertal children with short stature with normal response to a pharmacological stimulation test and subnormal 24-hour spontaneous GH secretion

Theres really no long-term human data

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