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Purpose-built for physicians No strong evidence to support discontinuation of GLP-1RAs prior to upper endoscopy Key takeaways: GLP-1RA use prior to upper endoscopy correlated with a higher rate of retained gastric content (OR = 5.56)

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2014 Apr;54(4):394-404

cyclisation broadens agonist activity across MC1R, MC3R, MC4R and MC5R and increases resistance to proteolytic cleavage, giving the non-selective profile that makes it the usual positive-control agonist in receptor assays

Physiol., vol

Adverse Reactions/Side Effects Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B12 (see WARNINGS)