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Substituting tirzepatide for semaglutide is a theoretical extension of that idea pairing an amylin analog with a more potent dual incretin agonist but it is important to repeat that this specific pairing has not been validated in a dedicated human combination trial

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Even small elevations in hs-CRP can signal ongoing immune activity and are linked to higher cardiovascular and metabolic risk

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The work below comes from preclinical studies, not from proven effects in people