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Weight regain after discontinuation is well documented, with studies showing that most patients regain 50 to 70 percent of lost weight within 12 months of stopping treatment

Davani-Davari D et al

Thermogenesis Heat production by the body, which increases energy expenditure

To become useful again, the body must use a specific enzyme called glutathione reductase to "recycle" it back into the reduced state

Concurrently, neuromodulators like dopamine, serotonin, and norepinephrine fine-tune taste sensitivity at both peripheral (taste buds) and central (reward circuitry) levels, linking chemosensation to motivational states

von Scholten, B