For now, the take-home messages for an informed patient or provider are: GLP-1 RAs (Ozempic, Wegovy, Mounjaro, etc.) are highly effective for T2D and obesity, offering glycemic control and substantial weight loss along with protective effects on the heart and possibly kidneys
Recently, GLP-1 was highlighted as a regulator of diverse pathways, but its potential as the therapeutic target of depressive disorder was not described comprehensively
In mitochondria, DHODH can reduce CoQ to ubiquinol (CoQH2), reducing oxygen free radicals, inhibiting the generation of phospholipid hydroperoxide (PLOOH), and inhibiting phospholipid peroxidation, thereby inhibiting ferroptosis
Serum cholesterol and leptin levels in patients with borderline personality disorder
Ribeiro F, Longobardi I, Perim P, Duarte B, Ferreira P, Gualano B, Roschel H, Saunders B
Biotechnol., 2020, 8)