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However, following Wegovy's 2024 FDA approval for cardiovascular risk reduction, CMS issued guidance allowing Medicare Part D plans to cover Wegovy when prescribed for its cardiovascular indication in eligible patients

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In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea