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In addition, SREBP-1c activation also inhibits carnitine palmitoyltransferase 1 (CPT1) through the generation of Malonyl-CoA, thereby inhibiting fatty acid entry into mitochondria for -oxidation, which further leads to lipid accumulation in the cell (Figure 3)

Lambert JD, Lee MJ, Lu H, Meng X, Hong JJ, Seril DN, et al

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