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Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years

Digestive conditions like Crohn's disease and celiac disease create similar absorption problems

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The compound has been considered in studies of SAM availability and methylation-dependent cellular mechanisms

Its a well-tolerated, low-risk option that provides fast, noticeable benefits

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