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If you eat mostly plant-based foods, it is critical to supplement B12

This usually occurs in individuals with underlying digestive conditions, those who have trouble absorbing all nutrients through digestion, or those with pernicious anemia, which specifically prevents B12 absorption

That's where treatments like injectable B12 for humans come into play

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

Push the plunger slowly to administer the full dose

Consuming an excess of B vitamins, vitamin C, and beta carotene may also be responsible