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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review
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Front Nutr 8:717740
Still, observable findings in study data typically follow a staged timeline: early physiological markers within the first one to two weeks, and measurable body-composition changes generally appearing over a four-to-eight-week research window
However, unlike traditional EPO, it does not increase red blood cell counts
This safety advantage makes it particularly attractive for patients who have experienced problematic side effects from other treatments
