Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
The STEP 1 extension found that the cardiometabolic improvements seen during treatment including blood sugar, blood pressure and cholesterol largely reverted toward baseline within a year of stopping
Free radicals are unstable molecules that can cause oxidative stressa process that can damage cells over time if left unchecked
Pharmacological Reports, 73 , 1020
Lipotropic injections begin influencing hepatic fat metabolism within 2448 hours of administration, but measurable body composition changes typically appear after 34 weeks of consistent dosing combined with caloric deficit
Manchikanti, L., Benyamin, R