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KossoffEHZupec-KaniaBAAuvinSBallaban-GilKRChristina BergqvistAGBlackfordRet al
The first readout, TRIUMPH-1 (obesity), was reported on 21 May 2026, with 28.3% mean weight loss at 80 weeks in the 12mg cohort (Pharmaceutical Journal)
Studies so far show that supplementation can reduce symptoms of depression, even compared to placebo
In a 12-week phase 2a study, individuals with obesity were treated with weekly doses of 4 mg, 6 mg, or placebo
Additionally, further investigations are underway to explore potential additional uses of tirzepatide in the clinical management of other cardiometabolic conditions associated with obesity, including heart failure and non-alcoholic (or metabolic-dysfunction associated) steatohepatitis (NASH/MASH)
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