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These findings led to Phase I and II clinical trials of T4 eyedrops (RGN-259) for dry eye and neurotrophic keratopathy, making the ocular surface one of the most clinically advanced use areas for the broader T4/TB-500 compound class

Astrocytes are fundamental elements in synapses, participate in synaptogenesis and maturation, and maintain synaptic homeostasis

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After the results are submitted to the agency, the FDA would review the results, as well as the drugs positive and negative effects, the treatments currently available for the proposed use, and more

Nevertheless, the trials showed a good safety profile for short-term use