UV exposure is another major variable: limited, controlled UV can augment and stabilize Melanotan II-induced tanning, while intense sun exposure increases the risk of burns and potential long-term skin damage on top of any drug-related risks
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
10.1016/S0165-2478(00)00170-X 7
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