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As a result, researchers theorize that murine models in the Ipamorelin groups could have consumed more food, leading to the observed weight gain

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In 1981, for example, a paper published in the International Journal of Clinical Pharmacology, Therapy, and Toxicology described a trial with six volunteers who experienced immediate sleep pressure after intravenous DSIP infusion, as well as increased sleep time, decreased sleep onset, and better sleep efficiency without any sedative effects.13 Three years later, two other human trials across ten test subjects with insomnia found that DSIP administration yielded statistically significant improvements in several key sleep measures fewer sleep arousals, greater sleep efficiency, and increased REM, spindle, and slow-wave sleep.14 The above studies had shortcomings, namely their very small sample sizes, but the sleep-improving effects in cases of insomnia point to DSIPs potential to live up to its name

Meet Our Experts See Our Editorial Policy Meet Our Health Expert Network Sandy Bassin, MD Medical Reviewer Member of American College of Lifestyle Medicine Sandy Bassin, MD, is an endocrinology fellow at Mount Sinai in New York City

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