FIGURE 3 Together, these findings suggest that HA + GSH-C4 induces a transient, reversible cytokine activation with repair-associated Th1/Th17 features, with IFN- and IL-12p70 persisting even after crossover to HA alone
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PubMed , PLoS Medicine , vol
At the cellular level, GLP-1RAs provide liver protection through three main pathways: reprogramming Kupffer cells to reduce inflammation, resetting metabolism via FXR/LXR-mediated lipid efflux, and directly promoting hepatocyte survival through the PI3K/Akt pathway
Wells, 1976