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Nevertheless, current studies on PCOS and the gut microbiome, particularly the fungal and viral components, remain limited, often constrained by small sample sizes, inadequate control for confounders, lack of causal mechanistic validation, and insufficient stratification of PCOS subtypes
Most advanced is tirzepatide, a GIP-GLP-1 co-agonist, which was recently approved for diabetes therapy in the US
Mucus and antimicrobial peptides secreted by goblet cells, as well as immunomodulatory proteins secreted by Paneth cells, can help to prevent the adhesion of pathogenic bacteria and viruses in the intestinal lumen (62, 63)
pneumoniae , adding GSH (6 mM) to meropenem resulted in a 2-log greater killing effect and lowered the antibiotics MIC several-fold
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