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The treatment discontinuation rate was 5.9%, higher than the placebo group, but most gastrointestinal adverse reactions were mild or moderate in severity

In support of a role for vagus-mediated CCK signaling, peripheral, but not central, antagonism of CCK-1R blocks the inhibitory effects of intestinal oleate and attenuates hindbrain activation 183

Macrophage-inducible C-type lectin signaling exacerbates acetaminophen-induced liver injury by promoting Kupffer cell activation in mice

These side effects can make it difficult to increase the dosage, which is necessary for effective weight loss

Patel V, Menezes H, Menezes C, Bouwer S, Bostick-Smith CA, Speelman DL

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