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We conducted a comprehensive literature search across databases, including PubMed and Web of Science, compiling data from clinical trials, case reports, and basic research studies published up to 2025, with a focus on the efficacy, safety, and mechanism of action of drugs such as liraglutide, semaglutide, and tirzepatide in patients with MC4R deficiency

Both are effective for weight loss, but Mounjaro (tirzepatide) has shown slightly greater average weight reduction in clinical trials compared to Wegovy (semaglutide)

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DeCotiis said she was not surprised