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Native IGF-1 is rapidly sequestered in circulation by IGF-binding proteins (IGFBPs 16), which extend its half-life but also restrict bioavailability

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Witort EJ, Pattarino J, Papucci L, Schiavone N, Donnini M, Lapucci A, Lulli M, Russo GL, Mori A, Dini M, Capaccioli S

the choice often depends on the pharmacys specific formulation goals and the providers recommendation