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Theranostics 11 (4), 19371952
Liver function effects of SGLT2 inhibitor and GLP-1 receptor agonist combination treatment in patients with type 2 diabetes (post hoc analysis of RECAP study)
In SCALE TEENS, the group receiving liragludtide had an estimated treatment difference in BMI of 5.01% compared with placebo, whereas the estimated treatment difference in STEP TEENS between the semaglutide and placebo groups was 16.7%
Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up
That said, the 1mg dose of semaglutide is what has shown effectiveness in most studies, so it should suffice for most patients
