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established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present
2021;75:e14771
Liposomal supplements will work much more effectively than non-liposomal forms
L.ShimabukuroR
For almost a century, not one harmful case of overdose has been recorded in medical literature
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