In addition to the US FDA approved GLP-1RAs, there are GLP1/glucagon dual agonists (Cotadutide, BI 456906), GIP/GLP1 dual agonists (Tirzepatide, GIP/GLP peptide I and II), GIP/GLP1/glucagon tri-agonists (HM15211, GGG tri-agonist) and GLP1R agonists (Efpeglenatide, Rybelsus) currently in phase 1- III clinical trials for T2D, obesity, and NASH (MASH) treatments (12)
It is the mechanism working
Once we move past the current hype phase and the dust settles, the rules of the road governing typical competitive dynamics of pharmaceutical prescription markets will re-establish themselves in obesity
NAD+ is a coenzyme studied in cellular-metabolism and aging research
Patients with a family history of medullary thyroid carcinoma should discuss risks thoroughly with their healthcare provider before starting therapy
However, it is always a good idea to consult with your healthcare provider before starting any new supplement