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Somatostatin then acts at the pituitary to suppress GH exocytosis
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The SHAPE study, analyzing real-world prescribing data, found: At 3 months: tirzepatide users lost 5.9% of body weight versus 3.6% for semaglutide At 6 months: 10.1% versus 5.8% At 12 months: 15.3% versus 8.3% These are averages from actual patients, not trial participants
The problem is that this same mechanism can cause discomfort before the body adapts
It's been studied by doctors and researchers around the world because it works so well
Attia SM, et al
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