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More thorough research trials are required to prove long-term safety and efficacy, despite encouraging preliminary evidence (7)
Additionally, GLP-1 receptor activity in the gut may affect intrinsic factor secretion and B12 absorption
It has been suggested that comparable conversion mechanisms occur in people when GABA is administered to transplanted human islets, leading to a reduction in -cell counts and a surge in beta-like cell numbers
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There is, however, some concern that GLP-1 RAs may affect the absorption of immunosuppressive drugs owing to their role in slowing gastric emptying.4,5 To date, data on tacrolimus doses and levels have been published on a small number of KT recipients treated with GLP-1 RAs.6,811 In our study, with a significant number of subjects, trough levels, doses and tacrolimus C/D ratio did not change significantly during follow-up, allowing confidence regarding the safety of immunosuppressive treatment
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