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Ongoing waves of SARS-CoV-2 infection sustain the scenario where in the absence of improved vaccines or immunotherapies, clinically vulnerable individuals will still require annual or biannual vaccinations with updated immunogens matched to circulating variants

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Performance of exercise with a strong eccentric component results in transient episodes of hypoxia, breakdown of ATP, accumulation of ADP within the smooth muscle of the precapillary sphincter, and activation of the enzyme adenylate kinase (24)

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